Re: TOJC: 11.7C
lietkeam@plu.edu
Mon, 09 Dec 1996 15:06:10 -0800 (PST)
uhlerdd-
My guess is that the Grignard reagent prefers the C=O bond to a
C=C bond. Perhaps in a reaction with a molecule containing a carbonyl
group, the Grignard reagent attacks that carbon first, and then if the
reaction with an alkene constituent does occur, it is at such a small
rate that it is negligible. There is probably a hierarchy of reactivity
with Grignard reagents, but I can't find it in our chapter.
-ahna
lietkeam@plu.edu
On Mon, 9 Dec 1996 uhlerdd@plu.edu wrote:
> Good Afternoon Everyone,
> In the discussion of Grignard reagents as nucleophiles it
> discusses the affinity these reagents have for unsaturated carbons,
> especially C=O bonds. With compounds such as alkene constituents on
> ketones, carboxylic acids or aldehydes what prevents reactions between the
> Grignard reagents and these unsaturated carbons.
>
>