@EhSCD1PULSE @?PLU CHEM 02APR923-PENTANONE IN CDCL3N CDCL3 + TMS[(50MG/500UL)ONE `D;Cp~ DE@9E` EE?DP)E8DzDuEXoE)V0*E EE(EPEȌ:E|`0E DnC DD`#DvhE@mEhE\EKE@%cEED`D`DE`DQ D@`E@DdEEȖ!Z8EEiD5EE`ȜE@[D').D %`DYD`7=E%`EDEpEE8EDh@D xE iED~CJE DY@tDD`Dp'Eȁ2}`D`EEpQECE}`NE \DDD D@FDMEyME&EE 3E Т0DE@0EBpEKE@0Ep CDCDp DP@bȃpHE^HED@#EE@xEPD0<&CPM EsDDWPDbD@;EC`DLE`jEP%DRS:DyEaEDCSE0D@CZC@DC@D`D BD^hE eE ECEE.Em[HD0@EHCC@DC@`D` E@DfCAE/ Ei`@j EPLPkEE(Ek0*E C`6Dg@OD;DQDa0DYEBE @E]EZ}D`%JC<0E DqDCDBDDDpE@7D CpR DDc D@C`DA"DD`DP `@DEhDDE`C`C@yDBBsD`C``DD D@D EbD D``DDCD@JC DQD@DDDxP@D@`D/DD D D=@DXBD=C%D@Bu==D- DCCD@D i& @FDD4D DuDjA@.DDC;=D@]C@ICDIHDYDD@~C4)MCY@;D&C@D@ D@"5@;2D@FDCApDQ D@di+DADjCC%DCBCA9C@DC@/lP@GD@VD"CCJD1D<`A@xCCCCZCkG-CC@@gCCC!@@C@DCC CBBCABC\C<BCCClC*CoBC"qC@CpCB;C`C@BdC:BCLsBC7CxBBeC"CYDA CCB -CB TB*"CBC1C*AB#CpBBC A<BB@ABdB` PBtB@B`HBp,BBADBBB@AB(B4BABB A `@ALBAHB,B@8BdA|t@ABBBXBBBB4BBBA8BdBBDB@d80ABBB@B@BBBD0BB$B@m@D@DCDpA?')D oDC/C D@zZD UDDBD`D^D]xY@*@ DC D@;D FDDjDDD`C oC@DD DDnCHDV@PD@yD@DC `CD`D@PDACD @]Dph;D+C:DG@ D(B``D@`D@]DC@E``D@/|DDBCD@<@D$ DW`DeCCDDp@v`D E= DD`DCn@}Co@UDC0tDC@Z@hD`E{`DD&0$EzDP@D `DDB`DXC}@;@zD`DD D@.D0 B9`!E`5EDLD/E@E 0V:DHDC@0D`8BD EDCP9E@ EPK1 D)0&EDDDB%@^D DDDP$`D-`OEEEPCE%@DD@ DSDND@k @DPE@D0 E;0IEpJD?`WEp ,ED@HD`EDC=DDD @QDU0_G D p@EBDE@kESC!?D DRDj D @-D'E@E@DCE@Da.D[B@?DCC` EaED1C02ED`'&oD`D/D DCDD@'DC$CD D0'<0D@EA D@D:D CC@WDB@JDuB@"RDD( DD9EpD@ C`@D@[@D3D0DQC'@8DWD/DDDB`DDGDC@DD``$D@DCDI `DEDDCDDAMDD@5D{D@cD?$%DC4D@TD`@' 8D@D DD@DCo8Bt8DiCDC@PCIpDoGD@ODDD :@}D;`DC6CiD@D ~BC BB DCBdx[DDCC D@1OD}NC%@D`B%CCpC~C@D\B~C"D@ DQ0;C@@NDC@DDBCCC`ACCCBDTDC@DCAC(CCC$CCD%C ?DC D@DDE;D:D E D$@lDqD0BB+D2Q` DaD DC E `DP @oD@P E@ DD`DC"@DD1D9 D ,z@D`"EDD@&E D` D@ssDC8,D C`DDDpED3PEECpDDjDAE@DB@SD D@E`/EbD`D@5E E5C` DDfDND$D@9D:@DDCD`D 30$DP7@;EKp E DED`1XB 7D@ND B@u@vD@'E@EEAE*DP)@&@DDCCDIC@D@D D@DED#`BE AECD E` E0vC@l D@XDC"4Do0@D@`2E@9D DP;E3EOC D 2 E@ D D DEXCDB!@DB DD@D)D@BKEp+EDBDE @D(_DW@DCCJ@`DP ED DP>E-`D<CADP0E'CD@D? D@~C@8@kDC$BDD `,pE DEC`D@)E` 'E!@D C`DC:DN C@D EC DE0%EAC p CP<EEDiC DTD3C$D@9D-@DCD@D@DD@a@ECCD?C{.D `lDD(@DD@!E@:D,Dn@DCBmD@C(@D`BC,BDNDCC{D@7@]DCDv5D@,DTDCACCCC BC6aD$D@-DTfD@YC5A@BDCCCACC}C@AD C@6@D@D?C CDC@ACdCCCp_C#DBC D DBBCT)CC2CDBCcCCWCBB CdCC?ClC@s>CB C.BT8BCCnC?C^C+wCzCBBCCA%CB4C1Cjz8CaCABnCdCsA%B)C@BCBA$C CC$9C98B A:CCBCDBBB ABB`BBAABBBlBAABHB B,B BAB\,BhABA?0B@@ 0B@`BA0ABB@HTBBB`BBB`0BhLBpAA0@@BAALB\BPABLBB BCBABB4BAB,B@@@@A@\ABBpBABB& ,B C<BlBBBltBA\Pp@dXBBBBCBp BCXBB@BBA,HA@`AD,BBA\BBBPB BB@BBB0B@@HAATB@|BBPABxBB CCBACB A@.C. D.C\@!Ds@ADDD`DD@@"D`x @D@6nDCHCD B"IDMDGD@D@D @w\ D `DCDDP@D =CCCC@P DL@DDCDDq@D@D;D3DW/D0BDBC]DG@^D`B@1@?DDDDDD@yAe@DCCCCQ`D8aDlD@DDDDH@DC[CgD C`C D5CAADNCu}D@U@DCCD1@xD @AC@@ DB CBxDmDQCC@D@%sD@@4wCzD@*DD7DCZCtCCD@CB5CoD@TD+D`DZDJ:CCsCC@ Dw@DCRD@CYC@jD&NDCC,DDC"CCC !&@#D MDBC:D7D@HB3CCCC!~CBCCCD!`BAC-$DcDC$DCpLBCBwCwCC'BCLCC@@DCHCCCACBSXBCACCnC HOCCSCCCAMCCBVCA="CCCCC*CE hC4pCBCW-B$CBCdB0BB B`BAHtBB@HBBB& B=CCB"CBBBAA 'CC@CC A@D{@$DC@bDP@Dsv'D;hDCC;D@DC/CCC5[ZZ+D@?DBDtDuDC@*bC<D CCC~C:DACEDiD@CM[aC D@aDDAgDCBCB D&dC@OC} DD@!DBD@vCD yD(1DCBDCUCADCCD_@D D0A@"DsDiDJB@CCCDMl1D@uDAHDDDCQB[D!DC@DB@/DDFDDnC@`jC`D@1D+DAC@D[KD@i7CSCCC#C@{`DD8DB@D@@rD`CD@DBC@LDD[C/D C[CeDN@GD @VD@D0@SDDDC@$@5C5@DBD4CAD@@DmDD D@Df AD3@{DCBRDrCsCD DDC@jBDpD@DCDuD @qC*DCC/ SqDD@DCDD E`BD D4XDxD|DDBpCWCD @9D` GD`DD DD@DGB@RDCCC @CHDa_DgD`D D@_DcDCCD'@#D$B @DB8B:DUC 8Di@DCCDl D@0CpHDbCC9C} DyDCCDiD SD@ D@DjDDXC FCCDCb DOAc D``DmDD`D`+D& @PD+GDCADBD@.DD@D D2 @DpDCCDiDfP@#CCCC@1{k@\D@9`DCCDMDA>`C`@uD[D@DvDB@DC6D@MD- CD@nD@QD`D`C2B@%CCCpCrC@MwDZD5D D`DD@8D@,RDUC8C@#DCCDC A@DCCmB@QDVDDCCDhDcBxC@C4B<C`2 D@cD8CCnDlDtB@8^C@lD0DD`-DACwCfCCOD,B&CaoDGD D~DMC@C@<DC|CC`C@DClB?D@(CNcP@ D@=DCC@DC`CwCCC &C@)KDC%D9D/:CCCCCs/C}m6C DCD}*D?6CBE@$DDCBDC @FC@CCB D~@DCB/D C".ACC B CCYFCLBSC`BBCC6CDBCCVCA=0CCBAC CwXBCCCC/C[AC cC!CfCg?YOCCCACUC#CCBCC)CJBBBC@\jWCOClBCC[CAVBC=C)C@?C!A|BHBBp#CPAKBCMCDCC\B@@TCBB<C@CCBA7C'CNd8DCFCBBCB B$BB BABCPBCd(CA8BC BBHB@ABBA0ABB(`B|BPB`ABLBt@BBBBBABBBBBhABpA\BtTBAB8BhBCBT BCAXBBBLAHBA BD0|BHB8BABB $B CBBh CBAB BAAPABAABB X B(C@ABCD!CB BBB`ABA@B??TBTB4B/CBCTC&hB @BBBAB4A`ApA0BxB<lBBPBBX C BB BDBBB B8ABA BA A,BABBBBC0BC)CpBPTB,B@AA`AdBBPBBB,<'B LCCC,C B( AAAAB<BLBAC C1B+!CTBBB,B,BLBA\BdBCBBC BAB@ABLBBClCB@C2B%0CB$B BAB(BB2CGBVpSC}CBBuC +C9\BTBBBt@NVC CB\BCmmC$ C~CB)CC, B(CABZC;HCCCCyCCCBP?LB]CAC@B3CyCcCC-CBTBCQC-CACZBB+CB<CBBCNCCADC|CnzCB$tCpA}|C_CBBCC=CCBCCCYCCVCC5C?wCDCC@DC=0a1D@HDCUC@6DChCBC|CA97D\DCZCvD,@Dw@IC8-DCCgC$CCB-C@DD@a,@eD@a@D$D@EDzcDEtCCC`hBC$CC@(WD@D@4DzD@{CTBu@D@-DC@D5C|CDC5D@CRLYD$`DCC~D7DN{#CCcC1C$D hDCC@~D@3\D@nCljDDDqD0CCCD^\C~DMND@ND>DgC9B@:@DkCCC#C@HDS1D$D:D@C UD.oDClCIDCKBCBB@DC@E [D4@DCCD@,pD@LC: D/CCYCC@BDCCXD@UD@@%@yC Dt@@D4D2@`D@6oCvCC.C@ D%)C @Ch@DVD6DDt@De@h#D@DC@DA D0DCAgD@XD{@?DJ@D(CCXD*D%h&CErCCC)JJT,D8`D+CC`D@ D`C+CkC`7DxCC,CB@DAC@D3DwA@!YC D@YD'DzD@<C#C-CCuCC&@?D2D D@uD^@Dd@l%D@:DUCC@DC@C@DB&CDCJlYD@5hDBC@ID5D@7ACCClCBC"SDD:D`D@mhC@-CV3DDCDBC8CC,D53C C@eVDPDCBgD! D@3]%CC3CCxCDC(B@>D@'CNs@LD@>D|BCDClCgCCtC{C@5DACD(D@'B-CC9CCxC*BCCC#D!UChB%DDCADVC]BC$BBCmC{@CDxCC"DCACCB BCB1jTCCB(CCCtCD8CC CdB@*CYtCB(CB}&CCCC DXC`ACSC*CLCiBUdCC/CC8CvCC!CBCC0C*CBx:CV_CcCBBCC/GCCCCjCn@I8C9CCdcCTBOQBCaCTCTC|B25BQHC BDC#CVSC2CBdBCSYCHqC?@CA,BCBB.C BlBFC*'Ch&CCCCwCCrB3 A6B<BB@@BLpB%C@B0CMCA+FBC\C CnC;B/x@B|BhB$BPBDBB(CBCCCBA;C B$BBTB CxBdABdB`BLBBLB|BPACB#3B0CBB!CCBB@@A\B,A<BXBA`ABBtB 1CBC|CBAB`BDB4B`?hBLBB B@XB CBB$CHBABPBdBBAH\B4BABAABBB CXB@B`B`B@BBLhBB@ABB BBBABBBhBBBAt BB@BBdBXBBpBB0BBTB BBB,BC BBBBBB|BB@BBhB@BABB\pBlBDBBA0xdBBAABB pTBC@BBLBA0DB BB B$@BChBxB4C$C:AB0CtBpBPAB,BAAhB4B&CZCAB2CCwCCh(BBBB"Ca@ oCCYCCCBdnB|C<BMC;CT?C C9CC=C;C_CBAC`C-B1dCPB\BC=C%CCB-CCC@CrCABGC-lBGKC[CBCCCeCDCCCB1KB';CB|pCAe8CCCC@ DSCACOC:CCk@ |CCfCxCbCCD7CCCCLxCCfCFnCC D(C9CDCDCC&CCboC~BC]CCC@@C@@$DCC DCCC|BACCC@D1CC0DCCCBCCBCPCoC DC@!=DC`UDDC&D3C^CCBCC@B ~C@AUDb/DDkDIC;XB DCCCHB CDCA.D$C? @RDHDGCkC@2DCCJCCgC@C@IDLBC@8D@BCABC(B@<AP $BA`A Cl CBACB dBB@ABxADHB\BAABBHBBA`BBXBPB4BBB?B*C`BBPCBAB@A\BA\pBC@BC6C;BAACBBC,B `B,BlB`B(A TBK[CGCC@ZC/B7tBB@B,lBHA Cx"CCzCaCvp,CJfCAB7CC@@B@@ABBD}]C4CBBC.{C?%[BR7CBCBB :CAB`C"hC# CCTGCYCCkTBB0C@BCC^C>C6CCjCCC BCCsDBBC |ChCCGpALC ;CCXC@B;CD:CCDCPCC8CCp"pBCCChDCCCCBCxCBC@BCCCDBmC DCfaCCBBCB\ECCCCDB4C@D$CCCBcCPC(CC CB@Dp@ DC?@"DCshC_CUCCCCbCHBDC@S)$C@DBRCDCCUCCpC[C,D8BC@DD&B1CCPCCSCBCCChD#C%C@/&D~DCTDwCBCBCeCnAD DCA@(D C@CC9C BC8C-CCA.CCCfCDACCC$CC*CpCBJC@DCC'D;CB C<CCCTC/CCC@NC0B$D@DCBDCC2^C;CCBBCB-C]HBCVCCCBCCCCCBJIBduC`ABbCXCAC&CHCACUChtCFCB`A|CBBBClCABC[gCeCCA!CC&C@ARC*7C$B@'C.LB$BWC'CCC,B_BCLC:C@rCLXBBC B@3C3B4AqmC^CCCnB`AgMC0CB$=C?B B-JC0ABCC,CTFB6CB4B3CBA2,C CCSC^dB.\BidC8C COC;BABPBBBA%CtC CjCTBZ~3CVCDBxBIC C BDHBHBlBPC3CBB=C CX$BB"DC0ABCCpBBBBBHBBxBBC@B#CBC C"ABC BB|B0BBDBBAhB CBCxCA B C0BBB Bl\BB@@xBA\ACBB C0BABlBBAB9AUCYCBdBPCC0B`DBAB,bC<@C"CCg Ct`aC5C,B B CTBtBC8BA0CCMhkC9dCBBLC)C+` BBBCB0A6BQC4CTCCBDAK%CHBBhBXB9C CACCBzXAC1CBLBC.,C240BABXB 0B|CC5CBCgC)CmCAB3CBB#ChBAqCe4CpCCA7CCCC?kCBHCBBCCCC-C] BCBCNC^CHhC;C6CACC*CCBBCX_ClAcXC BXCG]CCCBKCCrCAr CCCSCC-LBMyC!CC*CAxCCCCCCjJ|BgCB C`pRC5C B@BCBpBCABCCPSBPaC`C7C;C!ABB0B,B+A$BTCDCQCCBst,C'CLBABABBCUCTB^X$BC2C CBCFiC{7BBA B4ARC^CC@@C=CICCA CdC1%C-CC0tCBaI(BCyC.CCbCAAP%CTBCC<4VLCyCB4BCbAC*CBkC,BBCCBA"CPB*C6Clq CsCpCeCyCg,BB,C$BBBXB(VC C+CrCBX$A`CLCB AFCB BBAACBPAYGCQCBA~CAC\@VC &C0BACBhBC AhBCB;5BDCBB4CC,dB CXBPACBA#CBB#ChBBCBBBB"ClBB/C B?@3B (CAB CBB(BBpBB-CAB.C)CBAdB&C,BBBAPXBpB8BB@hBCpBC,#C0BABXBBPB BLxBB0AABC,C&@HBLBBCP]B|CCCaCCzB?AICTBBBXB+gC8=CCCCB1tC=CBBZCC@AB,BCFBE,AC2CCBCtCBd=CxBBCxIC'ACB.CdCOCCCCCBC  CBB